To win at Buffalo Gold slot machine, bet the maximum amount to increase your chances of hitting the jackpot. Utilize the bonus features such as free spins and multipliers to boost your winnings. Practice patience and persistence as winning may not happen right away. Keep an eye on the paytable to understand the winning combinations and payout values. Set a budget and stick to it to avoid overspending while playing the game. Remember that winning at slots is based on luck, so enjoy the game and have fun.