When selecting numbers for Powerball, consider choosing a mix of both high and low numbers to increase your chances of winning. Avoid selecting numbers in a sequence, as this is a common mistake made by many players. It is also recommended to include both even and odd numbers in your selection. Utilize a mix of your favorite numbers along with random selections to create a well-rounded combination. Lastly, trust your instincts and have fun with the process of choosing numbers for your Powerball ticket.