When searching for slots that payout the most, it is essential to consider the game’s return to player (RTP) percentage. Look for slots with an RTP of 96% or higher for better odds of winning. Progressive jackpot slots often offer the highest payouts, with prizes reaching millions of dollars. Pay attention to bonus features like free spins and multipliers, as they can significantly increase your winnings. Lastly, remember that luck plays a significant role in winning on slots, so gamble responsibly.