When looking for the best online slot payout, it is essential to consider the return to player (RTP) percentage of the game. Slots with a higher RTP offer better chances of winning in the long run. Additionally, pay attention to the volatility of the slot, as it determines the frequency and size of payouts. Researching and comparing different online casinos can help you find slots with the best payout rates. Keep in mind that progressive jackpot slots may offer massive payouts but usually have lower RTP. Lastly, setting a budget and playing responsibly are crucial when aiming for the best online slot payout.